BioOrbit is investigating the potential to manufacture cancer drugs in space.

An ESA BIC UK start-up is developing technology to build a pharmaceuticals factory in space that could help improve the lives of patients undergoing antibody treatments for cancer and other diseases.

Currently, for patients undergoing antibody cancer treatments, this involves spending hours at a time in hospital to undergo intravenous infusions, which are both time consuming and invasive.

To address this issue, start-up company BioOrbit is aiming to transform how this treatment is administered as it investigates the potential to manufacture antibody cancer therapy drugs in space. These drugs would be administered from the home just as with insulin, which is itself composed of small crystals.

Superior proteins

BioOrbit’s aim is to make antibody cancer treatments more accessible and convenient through a new approach, based on the crystallisation of drugs. If drugs are crystallised, they can be injected just under the skin, just as with insulin, which is itself, tiny crystals of insulin.

However, protein antibody drugs are especially hard to crystallise, and when this is done on earth, they are not high enough quality.

This is where space comes in. When antibodies are crystallised in space, in the absence of earth’s gravity, this allows for the creation of superior quality crystals compared to those formed on earth.

Manufacturing drugs in space

BioOrbit is one of the most recent innovative companies to join the European Space Agency Business Incubation Centre United Kingdom (ESA BIC UK).

Here it is poised to take its technology to the next level, by developing the necessary hardware for large-scale crystallisation in space for protein antibody drugs.

This technology has the potential to benefit patients in remote areas with limited access to hospitals, as well as to those that are immune compromised, who would benefit from staying away from hospitals.

Support for space tech start-ups

The ESA BIC UK is part of the world’s largest business incubation programmes for space tech start-ups, managed by the Science and Technology Facilities Council (STFC) in collaboration with:

• ESA
• UK Space Agency
• University of Leicester

Since 2011, it has supported more than 130 UK start-ups and entrepreneurs, using space and satellite technologies to develop new products and services across a diverse and exciting range of sectors, from sustainability to health technologies.

Start-ups involved with the ESA BIC UK have a 95% survival rate over five years following graduation from the programme, more than double the UK average, despite the economic uncertainties of the last few years.

Extraterrestrial testing

Katie King, founder and CEO of BioOrbit, said:

By taking antibodies into space and crystallising them there, where there is a superior crystallisation process, we can then bring that drug back down to earth and patients can treat themselves from the comfort of their own homes.

We are really excited to have joined the ESA BIC UK, which is invaluable to our business, particularly in terms of the business support and advice from important new connections we are making.

For BioOrbit, this is a really critical phase in the development of our technology, which we have tested and proved in principle. Through the ESA BIC UK, our sights are now set on building our payload and sending it in to space to see what data comes back.

Long term, our vision is to establish a pharmaceutical manufacturing facility in space within the next decade, enabling patients to access treatment conveniently at home.

Transformative potential

Paul Vernon, Executive Director of Business and Innovation at STFC, who also initiated the creation of the ESA BIC UK just over 10 years ago, said:

By developing a new generation of cancer therapy drugs in space, BioOrbit is pioneering a future where cancer patients can experience less invasive treatment from their own homes.

Their technology has the transformative potential to reshape the way we approach certain cancer treatments in the future, and could significantly improve the quality of life for cancer patients.

At the ESA BIC UK, this is exactly the kind of thing we set out to enable businesses to achieve, and which could generate far reaching benefits for our society and economy.